Publications

Engineering Science

Main Accomplishment

  • Having optimized the technique to fuse the lymphoma B with myeloma cells for hybridomas producing targeted MoAb.
  • Having set up and implemented the panel of in vitro and in vivo bioassays for drug discovery
  • Having cultured and maintained many cell lines.
  • Having tumorized mice for a model of testing anticancer drugs.

Patent 1:

  • Authors: Chau Van Minh, Phan Van Kiem, Hoang Thanh Huong, Nguyen Xuan Cuong, DoThi Thao, Ninh Khac Ban, Pham Quoc Long.
  • Name: The compound 3-[(6-O-Protocatechoyl-beta-D-glucopyranosyl-oxy)metyl]-furanon(CIBOTIUMBAROSIDE A) and the isolated method from the plant Cẩu tích Cibotium barometz
  • Number of Patent: 8834
  • Issue Date: 26/10/2010

Patent 2:

  • Authors: Chau Van Minh, Nguyen Hoai Nam, Phan Van Kiem, Nguyen Xuan Cuong, Nguyen Phuong Thao, DoThi Thao, Ninh Khac Ban, Nguyen The Cuong.
  • Name: The XYCLORTAN compounds and the isolated method from the plant Ba-bet-chum-to (Mallotus macrostachyus).
  • Number of Patent: 14352
  • Issue Date: 21/07/2015

Publications

1. N T Hoai, H V Duc, D T Thao, A Orav, A Raal (2015) Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells. Phcog. Mag. 11(44): S290-S295; ISSN: 0973-1296.

2. N H Nam, P T Tung, N T Ngoc, T T H Hanh, N P Thao, N V Thanh, N X Cuong, D T Thao, T T Huong, D C Thung, P V Kiem, Y H Kim, C V Minh (2015) Cytotoxic biscembranoids from the soft coral Sarchophyton pauciplicatum. Chem. Pharm. Bull. 63: 636-640. ISSN: 1347-5223

3. H L T Anh, N T Cuc, P H Yen, N X Nhiem, B H Tai, D T Thao, N H Nam, C V Minh, P V Kiem, Y H Kim (2015) Promising Anticancer Drug Candidates Based on the 7-methoxychromone Scaffold: Synthesis and Evaluation of Antiproliferative Activity; Lett Drug Des Discov 12(5): 385-392. ISSN: 1570-1808.

4. H L T Anh, N T Cuc, B H Tai, P H Yen, N X Nhiem, D T Thao, N H Nam, C V Minh, P V Kiem, Y H Kim (2015) Synthesis of Chromonylthiazolidines and their cytotoxicity to human cancer cell lines; Molecules, 20: 1151-1160. ISSN: 1420-3049.

5. D T Thao, C Y Huang, K T Lin, D T Phuong, N T Nga, N T Trang, N T Cuc, N X Cuong, N H Nam, C V Minh (2015) Using the Gene Expression Signature of Scutebarbalactone VN Isolated from Scutellaria barbata to Elucidate its Anticancer Activities. Nat Prod Commun. 10(2):353-355. ISSN 1555 – 9475

6. T H Nguyen, V D Ho, T T Do, H T Bui, V K Phan, K Sak, A Raal (2015) A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa. Nat. Prod. Res. 29(3):247-52. ISSN 1478-6247

7. Anh H L T, Hien NT, Hang DT, Ha TM, Nhiem NX, Hien TT, Thu VK, Thao do T, Van Minh C, Kiem PV (2014) Ent-Kaurane diterpenes from Annona glabra and their cytotoxic activities. Nat Prod Commun. 9(12):1681-2. ISSN 1555 – 9475.

8. V H Nguyen, V C Pham, H D T Mai, T N Le, T M H Nguyen, V N Vu, H G Tran, T T Do, W Dehaen, V M Chau (2014) Synthesis and biological evaluation of shikimic acid derivatives. Eur J Chem 5(4): 601-606. ISSN 2153-2249.

9. P T T Huong, C N Diep, N V Thanh, V A Tu, T H Hanh, N T Cuong, N P Thao, N X Cuong, D T Thao, T H Thai, N H Nam, N K Ban, P V Kiem, C V Minh (2014) A new cycloartane glucoside from Rhizophora stylosa. Nat Prod Commun 9(9): 1255 - 1257. ISSN 1555 – 9475.

10. V H Nguyen, V C Pham, T T Do, H D T Mai, N T Le, V N Vu, V H Tran, T M H Nguyen, W Dehaen, V M Chau (2014) Synthesis and Biological Evaluation of Oseltamivir Analogues from Shikimic acid. Nat Prod Commun 9(7): 977-980. ISSN 1555 – 9475.

11. D T Thao, D T Phuong, T T H Hanh, N P Thao, N X Cuong, N H Nam, C V Minh (2014) Two new neoclerodane diterpenoids from Scutellaria barbata D. Don growing in Vietnam. J Asian Nat Pro Res, 16(4): 364-369, ISSN 1028-6020

12. N V Minh, N L Anh, D T Thao, T K Vu (2014) Triazole-linked Chalcone and Flavone hybrid compounds based on AZT exhibiting in vitro anticancer activity. Lett Drug Des Discov 11(3): 297-303. ISSN 1570-1808.

13. N T Trang, D T Thao, N T Nga, D T Phuong, N T Cuc (2014) Production of nanosilver and in vitro determination of its activities. Vietnam Journal of Biotechnology 12(4): 639-645.

14. N T Cuc, D T Thao, N T Nga, D T Phuong, N T Trang (2014) Immunological response against tumors by using GLOBO H-KLH antigen vaccinated on mice. Vietnam Journal of Biotechnology 12(4): 623-629.

15. A V Trinh, H V Nguyen, Q L Pham, T A Luu, M C Nguyen, T T Do, T P Do, T I Cam, C B Pham, T A Nguyen (2014) Study on chemical constituents of the leaves of Ardisia splendens. Vietnam Journal of Science and Technology. 52 (5A): 712- 717.

16. T H Tran, T M Tran, H T Le, T M T Nguyen, T D Nguyen, T P Do, T T Do (2014) Chemical constituent and some biological activities of the Mangosteen pericaps. Vietnam Journal of Science and Technology. 52 (5B): 749- 755.

17. V D Ho, T B H Le, T H Nguyen, T T Do, V K Phan (2014) Chemical constituent and bioactivity of some Uvaria species (Annonaceae). Vietnam Journal of Science and Technology. 52 (5A): 284-295.

18. T H Tran, T M Tran, H T Tran, T Q Tran, T T H Dinh, T P Do. T T Do (2014) Study some biological activities of the Artocarpus Altilis moraceae. Vietnam Journal of Science and Technology. 52 (5A): 21-26.

19. V T Nguyen, T M Tran, H T Le, T Q Tran, T T Do, V C Pham, T H Tran (2014) Chemical constituents and some biological activities of the Chloranthus Erectus (Buch.- Ham) Verdcourt. Vietnam Journal of Science and Technology. 52 (5A): 27- 34.

20. N K Pham, T H Vu, T H Tran, V T Nguyen, T T Do, T C Nguyen, M C Nguyen (2014) Chrysoeriol preventing osteoporosis induced by prednisolone in BALB/c mice model. Journal of Science and Technology. 52 (5A): 350-357.

21. N T T Ha, D T Thao, T B Ngan, D T M Huong, N V Hung, M Litaudon, C V Minh, P V Cuong (2014) Cytotoxic bioactivities of Casearia grewiifolia Vent., Poikilospermum suaveolens (Blume) Merr. and Gymnosporia stylosa Pierre in Vietnam. Vietnam Pharmaceutial Journal. 54 (461): 30-34.

22. T T H Hanh, N T Ngoc, L D Dat, P T T Huong, N P Thao, N T Dat, D T Thao, N X Cuong, N H Nam, D C Thung, P V Kiem, C V Minh (2014) An anti-inflamation pyrrole oligoglycoside from the starfish Asterina batheri living in Vietnamese sea. Journal of Medicinal Materials 19(5): 279-283.

23. N T Nga, D T Phuong, N T Cuc, N X Cuong, N H Nam, D T Thao (2014) Study on in vitro anti-osteoporosis activities of scutebata S and scutebata T isolated from the Sctutelaria plant (Scutellaria barbata D. DON). Vietnam Journal of Biotechnology. 12(2): 213-219.

24. T Q Tran, T T Do, T D Nguyen (2014) Inhibitors of α- Glucosidase, α- Amylase and hypoglycaemic effects in Alloxan- Induced diabetic rats of extracts from Mulberry (Morus Alba) leaves. Proceedings of The Fourth Conference on Natural Product Research and Development (ISBN: 978-604-913-254-4): 225-230.

25. T Q Tran, T T Do (2014) Hypoglycemic effects of the extracts and safety of nutrition support for prevention and treatment of diabetes from sweet potato (Ipomoea Batatas (L.) Lam) leaves. Proceedings of the Fourth Conference on Natural Product Research and Development (ISBN: 978-604-913-254-4): 217-223.

26. T K Vu, S P Patil, Y J Park, D T Thao (2013) Synthesis and in vitro cytotoxic activity evaluation of novel Mannich bases and modified AZT derivatives possessing Mannich base moieties via click chemistry. Lett Drug Des Discov. 10(7): 585-593. ISSN 1570-1808.

27. N T Nga, D T Thao, N T Trang, D T Phuong, N T Cuc (2013) Establishment of three-dimenstional (3D) cell culture model to screen potential anticancer compounds. Vietnam Journal of Biotechnology 11(4): 631-637.

28. N T T Hà, T B Ngan, T V Hieu, P V Cuong, D T M Huong, N V Hung, M Litaudon, D T Thao, C V Minh (2013) Study on the chemical components of the plant Casearia grewiifolia belonged to the genus Mùng quân (Flacourtiaceae). Vietnam Journal of Chemistry. 51(6ABC): 54-58.

29. N Q Vuong, V V Chien, N T Thu, N T Hue, N T Dat, D T Thao, C V Minh, P V Cuong (2013) Synthetic process of lisinopril dehydrate, angiotensin conversting enzyme inhibitor. Proceedings of the 2nd VAST-KAST workshop on biodiversity and bioactive compounds. (ISBN: 978-604-913-143-1): 146-151.

30. N M Cuong, T T Huong, P N Khanh, T Q Toan, D T Thao, N T Cuc, B H Tai, S H Woo, C S Myung, Y H Kim (2013) Biological activities of natural products and derivatives from Vietnam medicinal plants. Proceedings of the 2nd VAST-KAST workshop on biodiversity and bioactive compounds. (ISBN: 978-604-913-143-1): 305-312.

31. M H T Tung, H V Duc, T T Huong, N T Duong, D T Phuong, D T Thao, B H Tai, Y H Kim, T T Bach, N M Cuong (2013) Cytotoxic compounds from Brucia mollis. Sci Pharm. 2013; 81: 819-831. ISSN 0036-8709

32. N K Ban, V H Giang, T M Linh, L Q Lien, N T Ngoc, D T Thao, N H Nam, N X Cuong, P V Kiem, C V Minh (2013) Two new 11-noriridoids from the aerial parts of Morinda umbellata. Phytochemistry Letters. 6: 267-269 ISSN 1874-3900

33. D T H Vien, D T Thao (2013) Preliminary findings on anticancer and lymphocyte stimulated activities of bioactive compounds extracted from Vietnam Carica papaya leaves. Journal of Food Science and Engineering. 3: 447-452. (ISSN: 2164-5795)

34. T T Huong, L H Tram, T T Quynh, N T Cuc, D T Thao, N T Nga (2013) Study on the anti-tumor activity of the plant Lược vàng (Callisia fragans) using the mice model induced by the high metastasis LLC cells (Lewis Lung Carcinoma). Vietnam Journal of Analytical Science. 18(3): 3-8.

35. N T Cuc, D T Thao, N T Trang, D T Phuong, N T Nga, N T Thang, T T Huong (2013) Studying on bioactivities of Garcinia mangostan pericarp. Proceedings of National Biotechnology Conference 2013. Vol.1: 605-609.

36. D T Thảo, D T Phương, N T Trang, N T Cuc, N T Nga, N T Thang (2013) GLOBO H-KLH conjugate exhibited highly effective immunogenic activity in BALB/c mice. Proceedings of National Biotechnology Conference 2013. Vol.1: 719-723.

37. H V Duc, L T H Oanh, N T Hoai, P V Kiem, D T Thao (2013) Cytotoxic effects of Uvaria cordata (Dun.) Wall. Ex Alston – Annonaceae on various cancer cell lines. Vietnam Journal of Medicinal Materials 18(2): 77-82.

38. H V Duc, L T B Hien, P V Kiem, D T Thao, N T Hoai (2013) Cytotoxic effects of fractions and polyoxygenated cyclohexen compounds isolated from Bu-de-tia (Uvaria grandiflora). Vietnam Pharmaceutical Journal 446: 7-12.

39. D T Thao, N B Mui, N T Trang, N T Nga, N T Cuc, D T Phuong, P K Dang (2013) Studying on creation of hybridomas producing monoclonal antibody specific for Follicle Stimulating Hormone (FSH). Vietnam Journal of Animal Husbandry Sciences and Technics; 4(169): 33-39.

40. L M Ha, D T Thao, C V Minh, N T Dat (2012) Toxicity and anticancer effect of Selaginella tamariscina extract on mice model. Nat. Prod. Res. 26(12): 1130-1134 ISSN 1478-6247

41. T T Do, P T Do, T T Nguyen, N T Nguyen, C Y Huang (2012) Study the anticancer mechanism of the promising compound 2B2D by using microarray technique. Vietnam Journal of Science and Technology. 50(3): 267-274.

42. N T Hoai, T T Diep, D T Thao, N K T Linh, N B Hien, H T D Huong (2012) Screening the Cytotoxic Activity of some medicinal plants of Pako and Van Kieu people in Quang Tri province. Vietnam Journal of Medicinal Materials 17(2): 95-100.

43. N T Hoai, T T Diep, D T Thao, N K T Linh, N B Hien, H T D Huong (2012) Screening the Antioxidant Activity of some medicinal plants of Pako and Van Kieu people in Quang Tri province. Vietnam Journal of Medicinal Materials 7(1): 8-13

44. N H Nam, P V Kiem, N K Ban, N P Thao, N X Nhiem, N X Cuong, C Tistaert, B Dejaegher, Y V Heyden, J Q-Leclercq, D T Thao, C V Minh (2011) Chemical constituents of Mallotus macrostachyus growing in Vietnam and cytotoxic activity of some cycloartane derivatives. Phytochemistry Letters. 4: 348-352. ISSN 1874-3900

45. N T Trang, D T Thao, D T Phuong, N T Cuc, N T Nga (2011) Developing BIOAFP-ELISA kit using monoclonal antibody AFP-2 to quantify -Fetoprotein. Vietnam Journal of Science and Technology. 49(6B): 25-31

46. D T Thao, D T Phuong, N T Nga, N T Trang, C Y Huang (2011) Conjugation of cDNA with the cyanine fluorescent for microarray experiment from the tRNA of the LU-1 cells under 2B2D treatment. Vietnam Journal of Biotechnology. 9(2): 163-168.

47. D T Phương, N T Cuc, N T Nga, N T Trang, D T Thao (2011) Knock-down ST3Gal-I gene by siRNA on the MCF-7breast cancer cells. Vietnam Medicine, 384(2): 165-170.

48. N T G An, D K Hieu, D V QuyEn, D T Thảo, D D Khang (2011) Study on immunized response activity of polyhedrin antigent from Monodon baculovirus (MBV) in BALB/c mice. Vietnam Journal of Science and Technology. 49(6): 25-32.

49. D T Phuong, N T Cuc, N T Trang, N T Nga, M S Tuan, M T Hang, D T H Ly, D T Thao (2010) Study on the anti-tumor activity of some compounds isolated from callus extract of the plant (Spilanthes acmella (L.) Murr) on mice. Vietnam Journal of Biotechnology. 8(3): 303-308.

50. T T Hà, T H Quang, N H Tùng, N X Nhiệm, N X Cường, N H Nam, N T Dat, H T Huong, D T Thao, Y H Kim, C V Minh, P V Kiem (2010) The steroids from soft coral Lobophytum laevigatum. Vietnam Journal of Science and Technology. 48(4A): 21-27.

51. D T Thao, N T Trang, N T Nga, N T Cuc, D T Phuong (2010) Studying on creation of hybridomas producing alpha-fetoprotein (AFP) monoclonal antibody for supporting early dianogsis of human hepatocellular carcinoma. Vietnam Medicine. 372(2): 90-94.

52. D T Thao, N T Hue, D T Phuong, N T Trang, N T Nga, N T Cuc (2010) Study on conjugating AFP monoclonal antibody with nanogold particle to dianogsis human hepatocellular cancer. Vietnam Journal of Biotechnology 8(3A): 647-652.

53. N T Nga, N T Cuc, N T Trang, D T Phuong, M S Tuan, M T Hang, D T H Ly, D T Thao (2010) Study the inhibition activity toward the growth of cancer cells cultured in vitro of several fractions extracted from Spilanthes acmella (L.) Murr callus. Vietnam Pharmaceutical Journal. 412(50): 41-44.

54. N T Trang, N T Cuc, D T Phuong, D T Thao (2010) Study on creation of hybridomas producing specific monoclonal antibody for progesterone. Vietnam Journal of Biology, 32(3): 90-94.