From 2005 to present:

• Biochemistry of proteins/enzymes and bio-active compounds.
• Exploitation and recombinant production of natural products and recombinant enzymes/proteins from bacteria, fungi and plants.
• Assembly principles and the virulence determinants of biofilms, as well as developing novel therapeutic approaches to prevent biofilm-dependent infectious diseases.
• Effects of different substances and their mode of action in distinct disease models, special studies on inflammation in vitro and in vivo (endotoxin-LPS and CASP-Colon Ascendens Stent Peritonitis models).
• Application of enzyme cytochrome P450s.
• Development of drugs, drug delivery systems and functional foods.

From 1993 to 2005:

• Metabolic processes in plants
• Study and application of bio-active compounds including ADN, proteins, enzymes, protein inhibitors and secondary metabolisms to agriculture, food industry, medicine, and environment protection.
• Application of biotechnology techniques to study plant biodiversities, identification, selection and creation of new varieties of plants with valuable genes.

RESEARCH PROJECTS

• "Development of a whole-cell biocatalyst for the transformation of sesquiterpene compounds"; International Foundation for Science (IFS), Sweden; 2016-2018
• "A reason for molecular polymorphism and possible cytotoxic and other activities of RNase homologues from venoms of snakes inhabiting Vietnam"; Vietnamese Academy of Science and Technology - International cooperation program; 2015-2016
• "Development of polymeric nanoparticle encapsulated mangostin (nanomangostin): a new approach to treating biolilm diseases"; Third World Academy of Science (TWAS), Italy, 2014-2016
• "Construction of a P450-based recombinant E. coli whole-cell biocatalyst for the production of new sesquiterpene derivatives"; National Foundation for Sciences and Technology (NAFOSTED); 2014-2016
• "Determination of hyaluronic acid in the aquatic waste and method for extraction"; Institute of Biotechnology; 2014-2015
• "Purified and biological activities of protease, polysaccharide from Pseuderanthemum palatiferum (Nees) Radlk"; Internatonal Foundation for Science (IFS), Sweden; 2013-2016.
• "Mechanisms of actions of phytochemicals against Streptococus mutans in biofilms"; National Foundation for Sciences and Technology (NAFOSTED); 2011-2014
• "Establishment of screening systems for novel anti-inflammatory agents using macrophage membrane bound glucocorticoid and toll-like family receptor"; Vietnam Academy of Science and Technology, Vietnam - VAST03; 2012-2013
• "Research and application of new wasteless, not using chemicals and environmentally friendly technology for processing waste shrimp shells that allows recovery of protein in this byproduct for the needs of nutrition"; Institute of Biotechnology, 2012-2013
• "Production of recombinant Bacillus secreted pectinase for cotton processing, Ministry of Science and Technology, Vietnam KC04.TN06/11-15; 2012
• "Production of synbiotics from bacterial spores and rice bran"; Ministry of Science and Technology, Vietnam KC04.TN01/11-15; 2012
• "New antimicrobial agents from the plants of Vietnam: improved protection against dental caries"; Internatonal Foundation for Science (IFS), Sweden F4087/2; 2011-2014
• "Pathoanalysis of disease larval bag (sacbrood) on foreign bees (Apis mellifera) and the general prevention measures", Ministry of Agriculture and Rural Development; 2011-2013
• Study on application of enzyme in preparing nanochitin for poduction of biosorbent used in the pharmaceutical industry", Ministry of Trade and Industry, Vietnam; 2011-2012
• "Production of mouthwash containing alpha-mangostin isolated from the peel of mangosteen (Garciana mangostana L.) grown in Vietnam"; Institute of Biotechnology; 2010-2012
• "Studies on hydrolysis of milk proteins by vegetable proteases to get milk hypoallergenic"; Vietnamese Academy of Science and Technology; International cooperation program; 2010-2011
• "Oxidative damage in oral streptococci", National Institute for Dental and Craniofacial Research, US; 2000-2011
• "The study on screening enzymes capable of hydrolyzing rutin into quercetin"; Institute of Biotechnology; 2009-2010
• "Screening and mode of actions of agents against dental caries"; Ministry of Science and Technology, Vietnam; 2006-2009
• "Screening for new alpha-glucosidase inhibitors from Vietnamese plants for the treatment of diabetes and obesity"; Institute of Biotechnology; 2007-2008
• "New antimicrobial agents from the plants of Vietnam: improved protection against dental caries"; Internatonal Foundation for Science (IFS) - F4087/1, Sweden; 2006-2008
• "Screening for new antimicrobial peptides from Vietnamse bioresources"; Institute of Biotechnology; 2006-2008
• "Research potential inhibition of the virus A/H5N1 reproduction by some enzymes from ribonuclease (RNase) group"; Institute of Biotechnology; 2006-2007
• "Study and application of bioactive preparations from naturally-occurring plants with medicinal potentially use for treatment of common diseases in Vietnam"; Ministry of Science and Technology; 2000-2005